Diet-Induced Acidosis As A Cause of Disease

The concept of diet-induced ‘acidosis’ as a cause of disease has been a subject of interest for more than a century. The present article reviews the history of our evolving understanding of physiological pH, the physiological support for the concept of ‘acidosis’, the causes of acidosis, how it is recognised, its short-term effects as well as the long-term clinical relevance of preventative measures, and the research support for normalization of body fluid pH.

The available research makes a compelling case that diet-induced acidosis…is a real phenomenon, and has a significant, clinical, long-term pathophysiological effect that should be recognized and potentially counter-balanced by dietary means. (1)

The researchers, Pizzornoa, Frassettoa and Katzinger have clearly identified that acidosis (increased acidity in the blood – pH below 7.365) is a very real threat to our health. Furthermore, my own research has shown that the effects of acidosis can directly contribute to various cancers, including pancreatic cancer, (2), (3), (12), arthritis (4), osteoporosis (5), cardiovascular disease, (6), diabetes (7), depression/psychological disfunctions (8), Crohn’s disease (9), and kidney disease (10). Yes, all of the top five killers in Western society and a whole heap more. Furthermore, my experience and the experience of those who have used my twelve week pH Miracle “LIFE” style, Alkaline Diet Course have given me significant proof that living alkaline also leads to weight/fat loss, muscle gain (also scientifically proven (11), energy increases, libido increases, skin improvements and more.

An Alkaline Diet and Cancer

Alkaline Minerals Prevent Cancer Growth In March 2009, Robey, Baggett, Kirkpatrick, et al published a paper in the American Association for Cancer Research Journal proving that alkaline minerals (in this case NaHCO3 – sodium bicarbonate) that increases the extracellular pH of cancer tumor cells and prevent metastasis. Their research shows that the pH of the tumors are always acidic and by using highly alkaline minerals to raise the pH – the growth of the cancer (and involvement of lymph nodes) is prevented.

Source: Cancer Research 69, 2260, March 15, 2009

Cancer Thrives in an Acidic Environment

In a Cancer Research Journal, in 2006, Gatenby, Gawlinski, et al researched and discovered that “chronic exposure of normal tissue to an acidic micro-environment produces toxicity by: (a) normal cell death… and (b) extracellular matrix degradation”. They proffer that glucose imbalance (an acid lifestlye) leads to a chronically acidic micro-environment (the normal cells and molecules that surround a tumor cell) which provides the perfect base for cancer.

Source: Cancer Research 66, 5216-5223, May 15, 2006

Acidosis and Osteoporosis
Alkaline Minerals Prevent Osteoporosis

A recently published study in the Journal of Clinical Endocrinology and Metabolism (Vol 94, No 1 96-102, 2009) has provided further evidence that the consumption of and supplementation with alkaline minerals is essential for good health. The objective of the study was to understand the effect of alkaline minerals (potassium bicarbonate, sodium bicarbonate and potassium chloride) on bone health – specifically, the ability of these alkaline minerals to slow the bone resorption rate and calcium excretion.

The participants who were taking the bicarbonate supplements had significant reductions in urinary N-telopeptide and calcium excretion when compared to the control group. This means that when taking the alkaline minerals, bones remained stronger and healthier.

Source: Journal of Clinical Endocrinology and Metabolism (Vol 94, No 1 96-102, 2009)
Cardiovascular Disease & the Alkaline Diet

Alkaline Minerals Critical to Prevention of CVD

In the Journal of Orthomolecular Medicine, Joseph Campbell provides a thorough review of the scientific literature surrounding minerals and disease and highlights that the alkaline minerals, magnesium and calcium, are critical to the prevention of cardiovascular disease (CVD). He also highlights that “Excessive consumption of acid producing foods, results in metabolic acidosis. When this occurs, the parathyroid hormone stimulates the removal of calcium from the bones and teeth (osteolysis), to buffer or neutralize the excess acidity. After many years, such calcium loss results in depleted bone, bone weakness and structure.”

Source: Journal of Orthomolecular Medicine Vol. 10, No. 3 & 4, 1995

Arthritis and Alkalinity

Alkaline Mineral Supplementation Decreases Pain in Rheumatoid Arthritis Patients

This incredible study from Institute for Prevention and Nutrition (Germany) provided clear and unquestionable evidence that using an alkaline mineral supplement (30g daily) reduced pain and increased movement in patients with moderately active Rheumatoid Arthritis over a 12-week period.

Source: The Open Nutrition Journal, 2008, 2, 100-105

Sources and References:

1. Diet-induced acidosis: is it real and clinically relevant? British Journal of Nutrition Cambridge University Press; Joseph Pizzornoa, Lynda A. Frassettoa and Joseph Katzingera

2. Acid-Mediated Tumor Invasion: a Multidisciplinary Study; Cancer Research 66, 5216-5223, May 15, 2006; Robert A. Gatenby, Edward T. Gawlinski, Arthur F. Gmitro, Brant Kaylor and Robert J. Gillies

3. The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion; Cancer Research 69, 2677, March 15, 2009; Ariosto S. Silva, Jose A. Yunes, Robert J. Gillies and Robert A. Gatenby

4. Alkaline Mineral Supplementation Decreases Pain in Rheumatoid Arthritis Patients; The Open Nutrition Journal, 2008, 2, 100-105; Regina Maria Cseuz, Istvan Barna, Tamas Bender and Jurgen Vormann

5. Treatment with Potassium Bicarbonate Lowers Calcium Excretion and Bone Resorption in Older Men and Women; The Journal of Clinical Endocrinology & Metabolism Vol. 94, No. 1 96-102; Bess Dawson-Hughes, Susan S. Harris, Nancy J. Palermo, Carmen Castaneda-Sceppa, Helen M. Rasmussen and Gerard E. Dallal

6. Minerals and Disease; Journal of Orthomolecular Medicine Vol. 10, No. 3 & 4, 1995; Joseph D. Campbell

7. Preservative Effect of Electrolyzed Reduced Water on Pancreatic b -Cell Mass in Diabetic db/db Mice; Biol. Pharm. Bull. 30(2) 234—236 (2007); Mi-Ja KIM, Kyung Hee JUNG, Yoon Kyung UHM, Kang-Hyun LEEM, and Hye Kyung KIM

8. The Effect of Acid/Alkaline Nutrition on Psychophysiological Function; Int J Biosocial Res. Vol.

9. (2); 182-202, 1987; Rudolf A. Wiley – Severe Osteomalacia Associated with Renal Tubular Acidosis in Crohn’s Disease; Digestive Diseases & Sciences, Vol 31, No 3, March 1986; Rui MM Victorino, Margarida B Lucas, Miguel Carneiro de Moura


10. Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment; American Journal of Kidney Diseases, Volume 45, Issue 6, Pages 978-993 J. Kraut, I. Kurtz

11. Lean Tissue: Alkaline diets favor lean tissue mass in older adults; American Journal of Clinical Nutrition, Vol. 87, No. 3, 662-665, March 2008; Bess Dawson-Hughes, Susan S Harris and Lisa Ceglia.

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