Turmeric Compound Boosts Regeneration of Stem Cells.

A bioactive compound found in turmeric promotes stem cell proliferation and differentiation in the brain, reveals new research. The findings suggest aromatic turmerone could be a future drug candidate for treating neurological disorders, such as stroke and Alzheimer’s disease.

The study looked at the effects of aromatic (ar-) turmerone on endogenous neutral stem cells (NSC), which are stem cells found within adult brains. NSC differentiate into neurons, and play an important role in self-repair and recovery of brain function in neurodegenerative diseases. Previous studies of ar-turmerone have shown that the compound can block activation of microglia cells. When activated, these cells cause neuroinflammation, which is associated with different neurological disorders. However, ar-turmerone’s impact on the brain’s capacity to self-repair was unknown.

Researchers from the Institute of Neuroscience and Medicine in Jülich, Germany, studied the effects of ar-turmerone on NSC proliferation and differentiation both in vitro and in vivo. Rat fetal NSC were cultured and grown in six different concentrations of ar-turmerone over a 72 hour period. At certain concentrations, ar-turmerone was shown to increase NSC proliferation by up to 80%, without having any impact on cell death. The cell differentiation process also accelerated in ar-turmerone-treated cells compared to untreated control cells.

To test the effects of ar-turmerone on NSC in vivo, the researchers injected adult rats with ar-turmerone. Using PET imaging and a tracer to detect proliferating cells, they found that the subventricular zone (SVZ) was wider, and the hippocampus expanded, in the brains of rats injected with ar-turmerone than in control animals. The SVZ and hippocampus are the two sites in adult mammalian brains where neurogenesis, the growth of neurons, is known to occur.

Lead author of the study, Adele Rueger, said: “While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine. Our findings on aromatic turmerone take us one step closer to achieving this goal.”

Ar-turmerone is the lesser-studied of two major bioactive compounds found in turmeric. The other compound is curcumin, which is well known for its anti-inflammatory and neuroprotective properties.

A Tumeric Recipe for the Prevention of Sickness and Disease

Mix 1/4 teaspoon turmeric with half teaspoon of olive oil. At that add greater pinch of fresh milled pepper. These three ingredients, mix in a cup. You can use this mixture itself but it also add a variety of dishes, soups, and salads. Just make sure that if you use them in cooked dishes, that these ingredients do not overcook it too, but adding them to the very end of. If they consume itself, mix them with a little water.

Turmeric is a spice in the form of a yellow powder, which is one component of curries. Its anti-inflammatory abilities are incredibly powerful. There is no other natural ingredient in the world which is more effective for reducing inflammation in the body of turmeric. molecules in turmeric causing the antiinflammatory effect called curcumin. Most recent studies have revealed that turmeric prevents many kinds of cancer, such as colorectal cancer, prostate cancer, brain cancer. experiments conducted on the mice, it was shown that as long as the mice were exposed to carcinogenic chemicals, as long as they use turmeric, developing several types of cancer was completely prevented. turmeric has only one drawback and that is that turmeric hard decomposes in the digestive tract. Therefore, the ideal combination for the treatment and prevention of cancer use turmeric in combination with pepper or ginger. Pepper according to research increases the effect of turmeric by 200 percent.

Story Source:
————————
BioMed Central. “Turmeric compound boosts regeneration of brain stem cells.” ScienceDaily. ScienceDaily, 25 September 2014. <www.sciencedaily.com/releases/2014/09/140925205819.htm>.

Journal Reference:
—————————
Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Fink, Michael Schroeter, Maria Rueger. Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Research & Therapy, 2014; 5 (4): 100 DOI: 10.1186/scrt500

http://www.sciencedaily.com/releases/2014/09/140925205819.htm

<img alt="Photo: Turmeric Compound Boosts Regeneration of Stem Cells. A bioactive compound found in turmeric promotes stem cell proliferation and differentiation in the brain, reveals new research. The findings suggest aromatic turmerone could be a future drug candidate for treating neurological disorders, such as stroke and Alzheimer's disease. The study looked at the effects of aromatic (ar-) turmerone on endogenous neutral stem cells (NSC), which are stem cells found within adult brains. NSC differentiate into neurons, and play an important role in self-repair and recovery of brain function in neurodegenerative diseases. Previous studies of ar-turmerone have shown that the compound can block activation of microglia cells. When activated, these cells cause neuroinflammation, which is associated with different neurological disorders. However, ar-turmerone's impact on the brain's capacity to self-repair was unknown. Researchers from the Institute of Neuroscience and Medicine in Jülich, Germany, studied the effects of ar-turmerone on NSC proliferation and differentiation both in vitro and in vivo. Rat fetal NSC were cultured and grown in six different concentrations of ar-turmerone over a 72 hour period. At certain concentrations, ar-turmerone was shown to increase NSC proliferation by up to 80%, without having any impact on cell death. The cell differentiation process also accelerated in ar-turmerone-treated cells compared to untreated control cells. To test the effects of ar-turmerone on NSC in vivo, the researchers injected adult rats with ar-turmerone. Using PET imaging and a tracer to detect proliferating cells, they found that the subventricular zone (SVZ) was wider, and the hippocampus expanded, in the brains of rats injected with ar-turmerone than in control animals. The SVZ and hippocampus are the two sites in adult mammalian brains where neurogenesis, the growth of neurons, is known to occur. Lead author of the study, Adele Rueger, said: "While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine. Our findings on aromatic turmerone take us one step closer to achieving this goal." Ar-turmerone is the lesser-studied of two major bioactive compounds found in turmeric. The other compound is curcumin, which is well known for its anti-inflammatory and neuroprotective properties. A Tumeric Recipe for the Prevention of Sickness and Disease Mix 1/4 teaspoon turmeric with half teaspoon of olive oil. At that add greater pinch of fresh milled pepper. These three ingredients, mix in a cup. You can use this mixture itself but it also add a variety of dishes, soups, and salads. Just make sure that if you use them in cooked dishes, that these ingredients do not overcook it too, but adding them to the very end of. If they consume itself, mix them with a little water. Turmeric is a spice in the form of a yellow powder, which is one component of curries. Its anti-inflammatory abilities are incredibly powerful. There is no other natural ingredient in the world which is more effective for reducing inflammation in the body of turmeric. molecules in turmeric causing the antiinflammatory effect called curcumin. Most recent studies have revealed that turmeric prevents many kinds of cancer, such as colorectal cancer, prostate cancer, brain cancer. experiments conducted on the mice, it was shown that as long as the mice were exposed to carcinogenic chemicals, as long as they use turmeric, developing several types of cancer was completely prevented. turmeric has only one drawback and that is that turmeric hard decomposes in the digestive tract. Therefore, the ideal combination for the treatment and prevention of cancer use turmeric in combination with pepper or ginger. Pepper according to research increases the effect of turmeric by 200 percent. Story Source: ———————— BioMed Central. "Turmeric compound boosts regeneration of brain stem cells." ScienceDaily. ScienceDaily, 25 September 2014. . Journal Reference: ————————— Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Fink, Michael Schroeter, Maria Rueger. Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Research & Therapy, 2014; 5 (4): 100 DOI: 10.1186/scrt500 http://www.sciencedaily.com/releases/2014/09/140925205819.htm” class=”scaledImageFitWidth img” height=”300″ src=”https://fbcdn-sphotos-d-a.akamaihd.net/hphotos-ak-xap1/v/t1.0-9/10639522_756781327712649_8372204343775986485_n.jpg?oh=90fc5b4326cf8e2c832a6d3c95066ee1&oe=54CE0C7E&__gda__=1417993378_b6e262e141c1ac61b544597abebd9aaa” style=”border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; height: auto; min-height: 100%; position: relative; width: 400px;” width=”400″ />

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