THE LINK BETWEEN pH AND ALZHEIMER’S
Just recently scientists have claimed that they have discovered new evidence that one of the plausible roots of Alzheimer’s disease could be a simple acid-alkaline pH imbalance in certain fluid areas of the brain.
In a new study from John Hopkins Medicine, mice with an Alzheimer’s gene were given histone deacetylase (HDAC) inhibitors. The experiment successfully reversed the pH problem and improved the capacity for amyloid beta clearance.
“By the time Alzheimer’s disease is diagnosed, most of the neurological damage is done, and it’s likely too late to reverse the disease’s progression,” says Professor of Physiology at the Johns Hopkins University, Rajini Rao.
“That’s why we need to focus on the earliest pathological symptoms or markers of Alzheimer’s disease, and we know that the biology and chemistry of endosomes is an important factor long before cognitive decline sets in.”
Nearly 20 years ago, scientists at Johns Hopkins and New York University discovered that endosomes, compartments that ferry molecules within cells, are larger and more abundant in the brains of people destined to develop Alzheimer’s disease. This hinted at an underlying problem that could lead to an accumulation of amyloid protein in spaces around neurons, says Prof. Rao.
To shuttle their cargo from place to place, endosomes use chaperones – proteins that bind to specific cargo and bring them back and forth from the cell’s surface.
Whether and how well this binding occurs depends on the proper pH level inside the endosome, a delicate balance of acidity and alkalinity, that makes endosomes float to the surface and slip back down into the cell.
Embedded in the endosome membrane are proteins that shuttle charged hydrogen atoms, known as protons, in and out of endosomes. The amount of protons inside the endosome determines its pH.
When fluids in the endosome become too acidic, the cargo is trapped within the endosome deep inside the cell. When the endosome contents are more alkaline, the cargo lingers at the cell’s surface for too long.
According to Robert O. Young, PhD., it all begins in the fluid spaces of the brain and certain cells called astrocytes. Astrocytes are responsible for cleaning up memory-destroying amyloid beta metabolic acid bound plaques between neurons. Normally, they do their job, and the metabolic acidic waste is eliminated during sleep preventing plaque buildup. But, when astrocytes are over-whelmed by the buildup of metabolic waste from bran cells, the acid bound plaque begin to build up within the brain to prevent damage to healthy brain cells, causing the hallmark signs of Alzheimer’s.
It turns out that this problem is caused by a simple pH imbalance inside crucial nutrient-transport fluid parts of brain cells. Scientists gave an HDAC inhibitor (a drug usually reserved for treating blood cancers) to pH imbalanced astrocytes with the Alzheimer’s genetic variant, and as internal pH was restored to a normal 7.365, astrocyte function and acid bound plaque cleanup was significantly improved.
“Simply improving the the alkaline pH environment around these brain cells improved overall function and clearance of the damaging acidic bound plaque as the body’s way of protecting healthy brain cells from the metabolic waste that was NOT eliminated during a restful sleep by the glymphatic system,” according to Robert O. Young, PhD. In fact Dr. Young suggests that ALL sickness and disease, including ALL cancers are the result of an over-acidification of the blood and then interstitial fluids due to an inverted way of living, eating, drinking, breathing and thinking.”
Of course, this research was conducted on lab-grown astrocytes, so it is far from conclusive, but it does bear promise for future research and treatment options. In the meantime, here are a few basic tips to reduce and eliminate acidity and encourage a balanced alkaline pH throughout your entire body and maintaining the its alkaline design.
HOW TO GET YOUR PH IN BALANCE
Start your day with a glass of alkaline water with chlorophyll and lemon
Chlorophyll is the major molecule of plants that make them green and is identical to human blood or hemoglobin other than their center atoms – chlorophyll has a center atom of magnesium and hemoglobin has a center atom or iron. In my research I have found that not only does chlorophyll detox the alimentary canal from food and drink acids but more important it builds healthy blood and its hemoglobin. This helps to increase oxygenation of the body and helps in the building of healthy body cells.
Adding lemon juice to your alkaline chlorophyll water will help in detoxing and alkalizing your body. You may think lemons are acidic, but lemon juice is actually alkaline-forming in the body. It’s the easiest (and tastiest) way to bring up the pH levels of your body fluids while ensuring your body is fully hydrated and ready to start the day clean and energetic. To purchase pure chlorophyll and lemon juice powders go to: http://www.ijuicenow.com
Finally, drinking alkaline chlorophyll water with lemon will neutralize the toxic acidic waste of hydrochloric acid in the stomach that is created when the stomach is producing sodium bicarbonate to alkalize acidic foods or liquids ingested or to buffer metabolic acidic waste in the blood, interstitial fluids and intracellular fluids of the body and especially the brain.
Steer clear of ALL sugars – Sugar in Any Form is Poison
Stay clear of ALL high sugar fruit, high sugar fruit juices, sugar junk foods and processed foods which are heavily acidic. As your body has a tendency to skew acidic over alkaline, it is important to reduce acid-promoting foods in your regular diet. Other acidic foods to be steer clear of include:
- all animal protein, including beef, chicken, duck, pork, and even fish
- all dairy products, including milk, cheese, yogurt and especially ice cream
- alcohol, including so-called nutritional products that contain alcohol or glycerin
- coffee, tea and chocolate
Eat ALL green vegetables, sprouts, grasses and low sugar fruit
- all leafy greens such as kale, spinach, arugula and butter lettuce
- broccoli, brussel sprouts,
- all low sugar fruit including cucumber, avocado, lemon, lime, green peppers, green olives and tomato
- all sprouts including bean, broccoli, alfalfa, etc.
- all green oils such as hemp, olive, and avocado
- all grasses including wheat grass, barley grass, lemon grass, oat grass, kamut grass, etc.
- seeds and nuts, especially almond and hazel nut milks
What promotes your body to become more alkaline? Green vegetables green grasses, cold-pressed green oils and and green fruit! So steam those greens, munch on some raw sprouts, or blend a little broccoli and avocado into a smoothie. A vegetable-heavy, plant-based diet can tilt the pH scales in your favor in maintaining the alkaline design of the body.
Manage physical and emotional stress better
Physical and emotional stress increases metabolic acidic waste that impairs your body’s ability to detoxify these inflammatory toxins via the lungs, kidneys, bowels and skin. Too little sleep and too little low-impact exercise does it, too. When the body is in deep sleep the glymphatic system removes toxic acidic metabolic waste from the brain. If this does not happen the increase in brain acidosis leads to the death of brain cells. Balance your lifestyle, practice meditation techniques, and get plenty of movement and rest in to ensure that your body and especially your brain cells are not swimming in a pool of acid.
The glymphatic system is a functional acidic waste clearance pathway for the vertebrate central nervous system (CNS). The pathway consists of a para-arterial influx route for cerebrospinal fluid (CSF) to enter the brain parenchyma, coupled to a clearance mechanism for the removal of interstitial fluid (ISF) and extracellular solutes from the interstitial compartments of the brain and spinal cord.
The name “glymphatic system” was coined in 2012 by the Danish neuroscientist Maiken Nedergaard in recognition of its dependence upon glial cells and the similarity of its functions to those of the peripheral lymphatic system. This system activates only when you are in deep sleep, removing metabolic acidic waste from the functioning of brain cells. When these metabolic acids build-up they can cause brain damage leading to cognitive disfunction and the condition dementia, leading to Alzheimers.
To learn how to prevent or reverse the symptoms of dementia and Alzheimer’s dis-ease read, The pH Miracle revised and updated and The pH Miracle for Cancer – http://www.phoreveryoung.com
To order alkalizing food, juices, nutritional supplements and light therapy for the brain go to: http://www.phoreveryoung.com, wwwijuicenow.com, http://www.innerlightblue.com, http://www.phmiracle.com and http://www.phmiraclestore.com
- Hari Prasad, Rajini Rao. Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH. Proceedings of the National Academy of Sciences, 2018; 115 (28): E6640 DOI: 10.1073/pnas.1801612115
- Johns Hopkins Medicine. “pH imbalance in brain cells may contribute to Alzheimer’s disease: Study identifies potential drug targets to reverse problem found in tiny organelles in astrocytes.” ScienceDaily. ScienceDaily, 2 August 2018. <www.sciencedaily.com/releases/2018/08/180802130758.htm>
- Young O. Robert. The pH Miracle for Cancer, Discover the Truth About the Cause, Prevention, Treatments and Reversals of All Types of Cancers, Hikari Publishing, Alpine, Utah, 2015 – http://www.phoreveryoung.com
- Young O. Robert, Young Redford Shelley. The pH Miracle, revised and updated, Balance Your Diet, Reclaim Your Health, Hachette Publishing, Wellness Central, 2010 – http://www.phoreveryoung.com