US National Library of MedicineNational Institutes of Health
Br J Cancer. 1999 Jun;80(7):1005-11.
Enhancement of chemotherapy by manipulation of tumour pH.
Raghunand N1, He X, van Sluis R, Mahoney B, Baggett B, Taylor CW, Paine-Murrieta G, Roe D, Bhujwalla ZM, Gillies RJ.
The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidiccompared to normal tissues. In-vitro, low pH reduces the uptake of weakly basic chemotherapeutic drugs and, hence, reduces their cytotoxicity. This phenomenon has been postulated to contribute to a ‘physiological’ resistance to weakly basic drugs in vivo. Doxorubicin is a weak base chemotherapeutic agent that is commonly used in combination chemotherapy to clinically treat breast cancers. This report demonstrates that MCF-7 human breast cancer cells in vitro are more susceptible to doxorubicin toxicity at pH 7.4, compared to pH 6.8. Furthermore 31P-magnetic resonance spectroscopy (MRS) has shown that the pHe of MCF-7 human breast cancer xenografts can be effectively and significantly raised with sodium bicarbonate in drinking water. The bicarbonate-induced extracellular alkalinization leads to significant improvements in the therapeutic effectiveness of doxorubicin against MCF-7 xenografts in vivo. Although physiological resistance to weakly basic chemotherapeutics is well-documented in vitro and in theory, these data represent the first in vivo demonstration of this important phenomenon.
PMID: 10362108 PMCID: PMC2363059 DOI: 10.1038/sj.bjc.6690455
Ariel Green reversed her medically diagnosed breast cancer with 3 cancerous tumors living the pH alkaline diet!
One of the 3 golf ball sized lumps in my breast that disappeared after changing to a pH alkaline diet.
The following is Ariel Green’s personal story of reversing her cancerous breast condition involving 3 tumors without surgery, chemotherapy and radiation!
“Do you have a health condition you think is incurable? Do you want to lose weight and keep it off permanently? Do you want to reverse aging? Do you do everything you can to be healthy but still don’t feel quite right? The alkaline diet could cure all this and more; but is it too good to be true?”
“The alkaline diet is quickly becoming popular with backing of celebrates like Kate Moss, Gwyneth Paltrow, Jennifer Aniston, Linda Gray, Bill Clinton, Larry Hagman, and Kirsten Dunst. In 2003 Cris Carr, former Budweiser girl, made a move documentary on her battle with cancer and how she reversed the cancer with an alkaline diet. You may have heard about the alkaline diet on the news or in one of several interviews on the Oprah Winery show. You can find testimonies of people all over the internet that completely reversed every day illnesses as well as cancer, HIV MS, diabetes type1&2, and other chronic diseases.”
“How does it work? The alkaline diet works on the premise that our bodies are self healing. In order for the body to heal itself it needs the right tools one being the correct pH, others being sufficient nutrients, water, and exercise. The main thing that affects our pH is our diets. By eating alkalizing foods and minimizing acidic foods our bodies can begin to heal, prevent sickness, and help protect from external acid factors like stress and radiation. To maintain a good pH in our bodies we need to eat at least 70% alkaline foods and no more than 30% mildly acidic foods. Alkaline foods include most cooked and raw vegetables, some beans, and few fruits, grains, & nuts. Acidic foods include meat, dairy, sugar, processed foods, coffee, and most fruits, grains, and nuts.”
“Sound too hard? Well, you don’t have to jump right in. Most people have better results by making slow gradual changes to their diet. Some people only need to make a couple of small changes to start seeing results. There are also many tasty alkaline versions of acidic foods; so don’t worry about felling deprived.”
“So does the alkaline lifestyle and diet really work? Apparently it does from all the testimonies on the internet. I tried it myself in 2006 when I found out I had three breast tumors that my doctor told me had to be surgically removed. Within six months the cancerous tumors were gone, and so were my allergies, chronic knee & back pain, and my problem with vertigo that my doctors could not explain or treat. I also have more energy and I don’t get colds anymore. I have been on the pH alkaline diet since 2006 and continue to maintain excellent health. I have met many people that have completely reversed their health problems with the pH alkaline diet. I also know a couple of people that it did not work completely for but it did drastically improve their health. Many people give up on alkalizing before it has a chance to work because they feel deprived. They think they can only eat salad; but this is not true.”
“Supplementation is also important as there are some vitamins and minerals than can be hard to get on an alkaline diet. There are also many supplements that can make alkalizing quicker and easier. The pH alkaline diet can be hard and take a long time to get results if you don’t know enough about it. So it is best to read up on it and get a good pH coach. There is very little clinical research on the pH alkaline diet and its effects on specific disease conditions. However, an article published in PubMed says there supporting research that shows the pH alkaline diet can support health and reverse disease but more research is needed http://www.ncbi.nlm.nih.gov/pubmed/22013455.”
“It will be many years before clinical research can be done on the pH alkaline diet with every health problem. So it is best to consult a health professional before changing your diet especially if you have a chronic disease.”
“Some health problems with supporting clinical studies on the alkaline diet & treatments include cancer, low back pain, bone loss, and increased lean tissue mass in older adults:”
“In a study published in PubMed a high pH treatment was tested on over 30 humans with cancer. In each case the cancer disappeared. http://www.ncbi.nlm.nih.gov/pubmed?term=6522424”
Supplementation with alkaline minerals reduces symptoms in patients with chronic lower back pain. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195546/?tool=pubmed”
“Increasing the alkaline content of the diet may slow bone loss in healthy older adults. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630872/”
“Alkaline diets favor lean tissue mass in older adults. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597402/”