Both Autism and Brain Cancer disorders involve faults in the same protein associated with excess acidity!
Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins University have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.
A summary of their work in human tumor cells and mice is published in the journal Nature Communications.
“My laboratory’s research on cargo transport inside the cells of patients with autism has led to a new strategy for treating a deadly brain cancer,” says Rajini Rao, Ph.D., a professor of physiology at the Johns Hopkins University School of Medicine. “This is a great example of the unexpected good that can come from going wherever the science takes us.”
All animal and human cells contain many “cargo packages” surrounded by membranes. These so-called endosomes carry newly minted proteins to specific destinations throughout the cell and haul away old proteins for destruction. Key to their “shipping speed” is the level of increased acidity inside the endosomes. This is controlled by balancing the activity of protein “pumps” that push protons into endosomes to increase their acidity with that of protein “leaks,” like NHE9, that remove protons.
Rao says: “Endosomes are like buckets of water that have to be kept full despite the leaks in them. Altering either the faucet or the leak rate can dramatically change the water level in the bucket.”
Rao’s research group previously showed that autism-associated defects in the protein NHE9 are harmful because they “clog the leaks,” leaving endosomes too acidic and making them race to remove cargo from the cell membrane, destroying proteins prematurely.
To better understand NHE9, graduate students and postdoctoral fellows in Rao’s lab searched through patient databases to see if it had other effects on human health. To their surprise, they found that elevated levels of NHE9 are associated with resistance to radiation, chemotherapy and poorer prognoses for patients with glioblastomas.
Teaming up with Alfredo Quinones-Hinojosa, M.D., a professor of neurosurgery at Johns Hopkins, the researchers examined NHE9 in tumor cells from several patients. Cells with low levels of NHE9 grew the slowest, the team found, and those with the highest levels grew fastest. Similarly, the cells with the most NHE9 traveled fastest when placed on a surface mimicking that of the brain, suggesting a high potential for metastasis. And this was confirmed when the tumor cells, which were manipulated to have high or low NHE9, were transplanted into the brains of mice.
Based on their autism research, the team suspected that the boost NHE9 gave to glioblastomas was explained by abnormal endosome acidity. Further studies revealed that, in contrast to autism, NHE9 is overactive in brain cancer, causing endosomes to leak too many protons and become too alkaline. This slows down the “shipping rate” of cancer-promoting cargo and leaves them on the cell surface for too long.
Research from other laboratories suggested that one such cargo protein is EGFR, which maintains cancer-promoting signals at the cell surface and helps tumors become more robust so they grow and move faster. It is also found at elevated levels in more than one-half of patients with glioblastomas. Drugs targeting EGFR in these patients are sometimes effective.
As they suspected, the team found that alkaline endosomes slow down the removal of EGFR from cell surfaces. Lab-grown tumor cells were more readily killed when treated with both a drug countering NHE proteins and a drug against EGFR than when treated by the EGFR-targeting drug alone.
Quinones-Hinojosa says: “We are still five to 10 years away from testing this idea in patients, but these results are encouraging. They give us a better idea of what to target so that hopefully we can make this disease less aggressive and less devastating.”
Kalyan C. Kondapalli, Jose P. Llongueras, Vivian Capilla-González, Hari Prasad, Anniesha Hack, Christopher Smith, Hugo Guerrero-Cázares, Alfredo Quiñones-Hinojosa, Rajini Rao. A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma. Nature Communications, Published February 9 2015. doi: 10.1038/ncomms7289
HUGE Victory For Mark and David Geier against the Lawless Maryland Medical Board
Maryland Medical Board, and the Individual Employees involved, ULTIMATELY
SANCTIONED by District Court – a Total Finding For the Plaintiff.
Damages Hearing to Follow.
Opinion by Consumer Advocate Tim Bolen
Thursday, January 15th, 2015
I predicted that this, or something like this, would happen. The Maryland Medical Board, and the employees that work there, are and were, completely out of control. They believed, and they believe now, that they are the ultimate law of the land, that they have no oversight, and that they are immune from scrutiny by the Maryland Legislature and the court system.
They also believe that they are not required to engage in “due process,” and that whatever rule or procedure they make up, for the moment, is uncontestable. I have seen, in my career, Boards that exhibited bad attitude, and were, hence, brought back under control, but I had never seen before anything like the employees of the Maryland Medical Board exhibited.
But that Maryland Medical Board has just come up against reality. A very experienced Maryland Judge, Ronald B. Rubin, on December 15, 2014 decided that he had had enough of the Maryland Board, and its individual employees involved in this debacle, and took an extraordinary step to smack these people back in line. He issued a “Default Judgment” in the case, long before it ever came to trial, pointing out that he, Judge Rubin, had given the Maryland Board EVERY opportunity to comply with the law, and they failed to do so. He did it, not on the merits of the case, but on the Maryland Board’s failure to comply with real “due process” in the court system itself. His eleven page Order, which is attached here, he made public.
More, and VERY IMPORTANT, is that the Judgment issued by Judge Rubin is against not just the Maryland Board as a public entity, but against INDIVIDUAL EMPLOYEES, individually, meaning that there are going to be some personal houses, cars, jewelry, seized, and salaries garnisheed, until their deaths, to pay the damages.
More, I predict, the Judge will, in the damages hearing, force the Board and its employees, to give the Geiers all of the discovery they sought in the first place – so that the Geiers can use it in their OTHER case. This coming time, I predict, Judge Rubin will have his courtroom packed with armed Montgomery County Deputy Sheriffs prepared to take to jail, immediately, not only the Maryland Board attorneys who fail to produce, but ALL of the named Defendants, under a “Contempt of Court” charge.
Now, we are getting somewhere.
The Autism Leadership world is divided into two groups – (1) Those that are Goal Centered and FUNCTION, and (2) Those that give the appearance of doing something, but actually accomplish nothing. NOTHING.
The Geiers belong to the first group, with over 250 publications in the area of effects of mercury in vaccines and medications, most of which are in peer-reviewed journals, they demonstrate a daily activism almost unparalleled. They travel around the world presenting at world health conferences on the problems of mercury. They testify in court, and design court cases, working with attorneys.
Unlike group (2) they are not interested in holding yacht parties. They have no interest in having their photo taken with a Congressman. You will find no pictures of them, on FaceBook, partying, with a drink in their hands. When they testify in front of a government committee they are prepared, and rely on science. They are not afraid to use the “V” word (Vaccines). When they speak, they speak the truth, and it resonates.
Which is why they are a target..
To read the entire article, click on:
PS Please support Dr. Robert O. Young in his battle for health freedom who is also being wrongfully persecuted in San Diego County, California by the out of control California Medical Board and the San Diego District Attorney and their employees. You can make donations to his legal defense fund at: www.phmiracleliving.com/t-Innerlight–Foundation.aspx
R.I.P. Dr. Mayer Eisenstein, MD
In Chicago, Homefirst Medical Services treats thousands of never-vaccinated children whose parents received exemptions through Illinois’ relatively permissive immunization policy. Homefirst’s medical director, Dr. Mayer Eisenstein, told us he is not aware of any cases of autism in never-vaccinated children; the national rate is 1 in 175, according to the Centers for Disease Control and Prevention. “We have a fairly large practice,” Eisenstein told us. “We have about 30,000 or 35,000 children that we’ve taken care of over the years, and I don’t think we have a single case of autism in children delivered by us who never received vaccines. “We do have enough of a sample,” Eisenstein said. “The numbers are too large to not see it. We would absolutely know. We’re all family doctors. If I have a child with autism come in, there’s no communication. It’s frightening. You can’t touch them. It’s not something that anyone would miss.”
Research scientist Stephanie Seneff of the Massachusetts Institute of Technology (MIT), a widely published author on topics ranging from Azlheimer’s Disease to autism and cardiovascular disease, raised plenty of eyebrows recently with a bold proclamation on autism at a special panel in Massachusetts about genetically modified organisms and other topics.
“At today’s rate, by 2025, one in two children will be autistic,” Seneff said last Thursday in Groton, MA at an event sponsored by the holistic-focused Groton Wellness organization.
Seneff presented slides showing a remarkably consistent correlation between the rising use of Roundup (with its active ingredient glyphosate) on crops and the rising rates of autism; while it doesn’t show a direct correlation it does give researchers plenty to think about, especially considering Seneff’s research into the side effects of autism that mimic glyphosate toxicity and deficiencies.
The slide notes that the heaviest use of Roundup, Monsanto’s flagship weedkiller, began in 1990 and continued to rise since. Meanwhile, the number of kids with autism has gone from 1 in 5,000 in 1975 to 1 in 68 today, a puzzling and frustrating stat that shows no signs of slowing down and one that correlates strongly with the rise in glyphosate use.
Of course, autism is a complex problem with many potential causes, but the numbers are particularly of note considering how close the correlation is, and Seneff’s credentials.
Dr. Seneff has written 10 papers (7 as the first author) in various medical and health journals on modern diseases as well as drug side effects, nutritional deficiencies and the impacts of environmental toxins on our health. She also worked as a Senior Research Scientist at the MIT Computer Science and Artificial Intelligence Laboratory before turning to biology, as her official biography notes.
EPA DEBATING ROUNDUP BAN OR RESTRICTIONS, ARE THEY BEING OBJECTIVE?
Recently, the group Moms Across America visited with officials from the EPA to discuss a potential ban or restrictions on Roundup, especially in light of recent findings that the active ingredient glyphosate is found in the breast milk of American mothers at levels that are a dangerous 760 to 1600 times higher than allowable limits in European drinking water.
While the group made its point loud and clear, it is well worth noting than many of the 100 studies provided for the EPA’s review were actually provided by the chemical companies themselves.
Urine testing has also shown that Americans have 10 times the glyphosate accumulation in their urine than Europeans, and children with autism have many biomarkers indicating excessive glyphosate in their systems including key mineral deficiencies, seizures and mitochondrial (the cell’s power center) disorders.
SENEFF RESPONDS TO MONSANTO’S KEY ARGUMENT
While Monsanto claims that Roundup is harmless because humans don’t have a shikimate pathway, which it inhibits, Seneff notes that our gut bacteria do have this pathway, and that’s crucial because these bacteria supply our body with crucial amino acids.
She also says that most studies are too short to show Roundup’s oft-studied effects as a cumulative toxin, one that builds up both in the environment and in our bodies over time.
According to Seneff, Roundup has the following side effects: it kills beneficial gut bacteria, allowing pathogens to grow; interferes with the synthesis of amino acids and methionine which leads to shortages in critical neurotransmitters and folate; chelates (removes) important minerals like iron, cobalt and manganese, and much more.
Additional chemicals in Roundup are untested because they’re classified as “inert,”she notes in her presentation, butaccording to a 2014 study in BioMed Research International they are capable of amplifying the ill effects of Roundup hundreds of times over.
To learn more about Seneff’s warning over autism and Roundup accumulation, you can view her slideshow on the topic. Until then, it’s best to exercise caution, and to buy and grow organic food whenever possible.
Dr. Stephanie Seneff, senior researcher at MIT, speaking at this year’s Autism One conference:
In what is perhaps the biggest news event of the year (that the mainstream media does not want to cover), the full ramifications of Dr. William Thompson of the CDC coming forward as a whistleblower to confess that the CDC has covered up data linking vaccines to autism are yet to be seen. (See: CDC Whistleblower: CDC Covered Up MMR Vaccine Link to Autism in African American Boys)
However, while blame and (hopefully) criminal complaints more than likely await many people who participated in this cover-up, there is one man who deserves honor, and to whom the mainstream media owes a huge apology: Dr. Andrew Wakefield.
Dr. Wakefield is the world-renowned gastrointestinal surgeon and researcher who has been accused of fraud and fabricating studies that show a link between the MMR vaccine and bowel disease, present in many children with autism. Dr. Wakefield was not an anti-vaccine doctor. Rather, he was a doctor interested in vaccine safety, and his studies led him (and many other researchers) to believe that there were problems with the three-combo vaccine of measles, mumps, and rubella (MMR). He did not advise his patients to stop vaccinating, but instead to vaccinate for these three diseases with single vaccines, rather than the combo.
There was just one problem with this advice. While this advice was in the best interest of parents seeking vaccine safety, it was not in the best interest of the manufacturer of the MMR vaccine (Merck), which saw a decline in its sales in the UK (although there was initially an increase in the sale of single-dose vaccines).
Dr. Wakefield’s research regarding the MMR vaccine and its link to bowel disease and autism was originally published in the Lancet. But a journalist by the name of Brian Deer published an article in the British Medical Journal criticizing Dr. Wakefield and accusing him of fraud. As a result, his study in the Lancet was retracted. Dr. Wakefield, and one of the co-authors of the retracted article, Prof. John Walker-Smith, were barred from practicing medicine by the United Kingdom’s General Medical Council regulatory board.
What you will not read in the mainstream media, however, is that both the BMJ and Lancet have strong financial ties to the manufacturer of the MMR vaccine. (See: BMJ & Lancet Wedded to Merck CME Partnership) You probably also did not read that Dr. Andrew’s co-author in the study, Prof. John Walker-Smith, fought an expensive legal battle against the United Kingdom’s General Medical Council and won. He was completely exonerated.
Dr. Andrew Wakefield, in the meantime, lost his career and name for simply following the truth his research led him to. He became the scapegoat, the “straw man” to knock down in the mainstream media. Every time someone would bring up any question regarding vaccines and autism you will usually encounter something like: “That theory has been totally proven false, and the guy who made it up was convicted of fraud.” I have even had people tell me on social media that “the guy” (most don’t even know his name) did “prison time.”
However, Dr. Wakefield was never convicted by a jury or in a court of law, and he lives in the U.S. today. He has issued challenges to his accusers to debate him in the media, but of course they have never accepted his challenge. He is a leading expert in gut health, a subject sorely needing research today, in an age where not only vaccines, but antibiotics, pesticides, and many other things have destroyed our ability to digest our food properly, leading to many bowel diseases. A list of his research, provided from his Facebook Page, is listed below.
If you want to know what people who personally know Dr. Wakefield think about him, read this report from one of the parents of two children that were part of his study that was allegedly “fabricated.” Dr. Wakefield was so successful in working with parents and children in in the U.K., helping them to find solutions to complicated health problems, that a British TV program was made dramatizing his work in the 1990s. It recently resurfaced on YouTube here.
UPDATE 9/5/2014: Judge: Lawsuit Against Merck’s MMR Vaccine Fraud to Continue