Both Autism and Brain Cancer disorders involve faults in the same protein associated with excess acidity!
Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins University have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.
A summary of their work in human tumor cells and mice is published in the journal Nature Communications.
“My laboratory’s research on cargo transport inside the cells of patients with autism has led to a new strategy for treating a deadly brain cancer,” says Rajini Rao, Ph.D., a professor of physiology at the Johns Hopkins University School of Medicine. “This is a great example of the unexpected good that can come from going wherever the science takes us.”
All animal and human cells contain many “cargo packages” surrounded by membranes. These so-called endosomes carry newly minted proteins to specific destinations throughout the cell and haul away old proteins for destruction. Key to their “shipping speed” is the level of increased acidity inside the endosomes. This is controlled by balancing the activity of protein “pumps” that push protons into endosomes to increase their acidity with that of protein “leaks,” like NHE9, that remove protons.
Rao says: “Endosomes are like buckets of water that have to be kept full despite the leaks in them. Altering either the faucet or the leak rate can dramatically change the water level in the bucket.”
Rao’s research group previously showed that autism-associated defects in the protein NHE9 are harmful because they “clog the leaks,” leaving endosomes too acidic and making them race to remove cargo from the cell membrane, destroying proteins prematurely.
To better understand NHE9, graduate students and postdoctoral fellows in Rao’s lab searched through patient databases to see if it had other effects on human health. To their surprise, they found that elevated levels of NHE9 are associated with resistance to radiation, chemotherapy and poorer prognoses for patients with glioblastomas.
Teaming up with Alfredo Quinones-Hinojosa, M.D., a professor of neurosurgery at Johns Hopkins, the researchers examined NHE9 in tumor cells from several patients. Cells with low levels of NHE9 grew the slowest, the team found, and those with the highest levels grew fastest. Similarly, the cells with the most NHE9 traveled fastest when placed on a surface mimicking that of the brain, suggesting a high potential for metastasis. And this was confirmed when the tumor cells, which were manipulated to have high or low NHE9, were transplanted into the brains of mice.
Based on their autism research, the team suspected that the boost NHE9 gave to glioblastomas was explained by abnormal endosome acidity. Further studies revealed that, in contrast to autism, NHE9 is overactive in brain cancer, causing endosomes to leak too many protons and become too alkaline. This slows down the “shipping rate” of cancer-promoting cargo and leaves them on the cell surface for too long.
Research from other laboratories suggested that one such cargo protein is EGFR, which maintains cancer-promoting signals at the cell surface and helps tumors become more robust so they grow and move faster. It is also found at elevated levels in more than one-half of patients with glioblastomas. Drugs targeting EGFR in these patients are sometimes effective.
As they suspected, the team found that alkaline endosomes slow down the removal of EGFR from cell surfaces. Lab-grown tumor cells were more readily killed when treated with both a drug countering NHE proteins and a drug against EGFR than when treated by the EGFR-targeting drug alone.
Quinones-Hinojosa says: “We are still five to 10 years away from testing this idea in patients, but these results are encouraging. They give us a better idea of what to target so that hopefully we can make this disease less aggressive and less devastating.”
Kalyan C. Kondapalli, Jose P. Llongueras, Vivian Capilla-González, Hari Prasad, Anniesha Hack, Christopher Smith, Hugo Guerrero-Cázares, Alfredo Quiñones-Hinojosa, Rajini Rao. A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma. Nature Communications, Published February 9 2015. doi: 10.1038/ncomms7289
The following is another unsolicited pH Miracle Testimony on reversing Autism from Tony Paterniti:
Our 21-year-old, severely autistic daughter (low-functioning) met Dr. Young last night. He spent some time connecting with her and sorted out the extreme crisis she had been going through for the past week – thrashing wildly about in apparent pain, with loud vocalizations and no sleep for a full week.
We applied his immediate suggestions, and by the time we got home at around 10 p.m. (the meeting was some distance from our home), she was quiet and still. Heading up to bed an hour later, we could see the exhaustion of the past week finally descending upon her, looking for rejuvenation – and knowing she would find it.
Elena slept peacefully through the night. By morning, it was clear that the serious gut issues Dr. Young had tuned in on had been cleared – at least for the moment. Clearly, we are now on a path with Elena that can only lead to more good, more health and greater well-being.
And for this, we feel extremely grateful and happy.
Blessings on you and on your assistants, Dr. Young – Especially during Elena’s time of extreme crisis, you were – and are – a godsend.
Tony & Ziek Paterniti
HUGE Victory For Mark and David Geier against the Lawless Maryland Medical Board
Maryland Medical Board, and the Individual Employees involved, ULTIMATELY
SANCTIONED by District Court – a Total Finding For the Plaintiff.
Damages Hearing to Follow.
Opinion by Consumer Advocate Tim Bolen
Thursday, January 15th, 2015
I predicted that this, or something like this, would happen. The Maryland Medical Board, and the employees that work there, are and were, completely out of control. They believed, and they believe now, that they are the ultimate law of the land, that they have no oversight, and that they are immune from scrutiny by the Maryland Legislature and the court system.
They also believe that they are not required to engage in “due process,” and that whatever rule or procedure they make up, for the moment, is uncontestable. I have seen, in my career, Boards that exhibited bad attitude, and were, hence, brought back under control, but I had never seen before anything like the employees of the Maryland Medical Board exhibited.
But that Maryland Medical Board has just come up against reality. A very experienced Maryland Judge, Ronald B. Rubin, on December 15, 2014 decided that he had had enough of the Maryland Board, and its individual employees involved in this debacle, and took an extraordinary step to smack these people back in line. He issued a “Default Judgment” in the case, long before it ever came to trial, pointing out that he, Judge Rubin, had given the Maryland Board EVERY opportunity to comply with the law, and they failed to do so. He did it, not on the merits of the case, but on the Maryland Board’s failure to comply with real “due process” in the court system itself. His eleven page Order, which is attached here, he made public.
More, and VERY IMPORTANT, is that the Judgment issued by Judge Rubin is against not just the Maryland Board as a public entity, but against INDIVIDUAL EMPLOYEES, individually, meaning that there are going to be some personal houses, cars, jewelry, seized, and salaries garnisheed, until their deaths, to pay the damages.
More, I predict, the Judge will, in the damages hearing, force the Board and its employees, to give the Geiers all of the discovery they sought in the first place – so that the Geiers can use it in their OTHER case. This coming time, I predict, Judge Rubin will have his courtroom packed with armed Montgomery County Deputy Sheriffs prepared to take to jail, immediately, not only the Maryland Board attorneys who fail to produce, but ALL of the named Defendants, under a “Contempt of Court” charge.
Now, we are getting somewhere.
The Autism Leadership world is divided into two groups – (1) Those that are Goal Centered and FUNCTION, and (2) Those that give the appearance of doing something, but actually accomplish nothing. NOTHING.
The Geiers belong to the first group, with over 250 publications in the area of effects of mercury in vaccines and medications, most of which are in peer-reviewed journals, they demonstrate a daily activism almost unparalleled. They travel around the world presenting at world health conferences on the problems of mercury. They testify in court, and design court cases, working with attorneys.
Unlike group (2) they are not interested in holding yacht parties. They have no interest in having their photo taken with a Congressman. You will find no pictures of them, on FaceBook, partying, with a drink in their hands. When they testify in front of a government committee they are prepared, and rely on science. They are not afraid to use the “V” word (Vaccines). When they speak, they speak the truth, and it resonates.
Which is why they are a target..
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PS Please support Dr. Robert O. Young in his battle for health freedom who is also being wrongfully persecuted in San Diego County, California by the out of control California Medical Board and the San Diego District Attorney and their employees. You can make donations to his legal defense fund at: www.phmiracleliving.com/t-Innerlight–Foundation.aspx