Tag Archives: Stanford University School of Medicine

Dr. Robert O. Young’s 1994 Biological Transformation Research Validated – Pleomorphism or Biological Transformation is a Reality in 2 Studies!

Human Skin Cells Converted Into Embryonic Stem Cells: First Time Human Stem Cells Have Been Produced Via Nuclear Transfer

Dr. Robert O. Young documented the reality of biological transformation of body cells in June of 1994 with the nuclear transfer of red blood cells into bacteria and bacteria into red blood cells.  Now scientists at Oregon Health & Secience University, Oregon National Primate Research Center and Stanford University have also documented the reality of biological transformation or pleomorphism of one cell such as skin cells to embryonic stem cells capable of transforming into other cell types.
May 15, 2013 — Scientists at Oregon Health & Science University and the Oregon National Primate Research Center (ONPRC) have successfully reprogrammed human skin cells to become embryonic stem cells capable of transforming into any other cell type in the body. It is believed that stem cell therapies hold the promise of replacing cells damaged through injury or illness. Diseases or conditions that might be treated through stem cell therapy include Parkinson’s disease, multiple sclerosis, cardiac disease and spinal cord injuries.
The research breakthrough, led by Shoukhrat Mitalipov, Ph.D., a senior scientist at ONPRC, follows previous success in transforming monkey skin cells into embryonic stem cells in 2007. This latest research will be published in the journal Cell online May 15 and in print June 6.
The technique used by Drs. Mitalipov, Paula Amato, M.D., and their colleagues in OHSU’s Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, is a variation of a commonly used method called somatic cell nuclear transfer, or SCNT. It involves transplanting the nucleus of one cell, containing an individual’s DNA, into an egg cell that has had its genetic material removed. The unfertilized egg cell then develops and eventually produces stem cells.
“A thorough examination of the stem cells derived through this technique demonstrated their ability to convert just like normal embryonic stem cells, into several different cell types, including nerve cells, liver cells and heart cells. Furthermore, because these reprogrammed cells can be generated with nuclear genetic material from a patient, there is no concern of transplant rejection,” explained Dr. Mitalipov. “While there is much work to be done in developing safe and effective stem cell treatments, we believe this is a significant step forward in developing the cells that could be used in regenerative medicine.”
Another noteworthy aspect of this research is that it does not involve the use of fertilized embryos, a topic that has been the source of a significant ethical debate.
The Mitalipov team’s success in reprogramming human skin cells came through a series of studies in both human and monkey cells. Previous unsuccessful attempts by several labs showed that human egg cells appear to be more fragile than eggs from other species. Therefore, known reprogramming methods stalled before stem cells were produced.
To solve this problem, the OHSU group studied various alternative approaches first developed in monkey cells and then applied to human cells. Through moving findings between monkey cells and human cells, the researchers were able to develop a successful method.
The key to this success was finding a way to prompt egg cells to stay in a state called “metaphase” during the nuclear transfer process. Metaphase is a stage in the cell’s natural division process (meiosis) when genetic material aligns in the middle of the cell before the cell divides. The research team found that chemically maintaining metaphase throughout the transfer process prevented the process from stalling and allowed the cells to develop and produce stem cells.
“This is a remarkable accomplishment by the Mitalipov lab that will fuel the development of stem cell therapies to combat several diseases and conditions for which there are currently no treatments or cures,” said Dr. Dan Dorsa, Ph.D., OHSU Vice President for Research. “The achievement also highlights OHSU’s deep reproductive expertise across our campuses. A key component to this success was the translation of basic science findings at the OHSU primate center paired with privately funded human cell studies.”
One important distinction is that while the method might be considered a technique for cloning stem cells, commonly called therapeutic cloning, the same method would not likely be successful in producing human clones otherwise known as reproductive cloning. Several years of monkey studies that utilize somatic cell nuclear transfer have never successfully produced monkey clones. It is expected that this is also the case with humans. Furthermore, the comparative fragility of human cells as noted during this study, is a significant factor that would likely prevent the development of clones.
“Our research is directed toward generating stem cells for use in future treatments to combat disease,” added Dr. Mitalipov. “While nuclear transfer breakthroughs often lead to a public discussion about the ethics of human cloning, this is not our focus, nor do we believe our findings might be used by others to advance the possibility of human reproductive cloning.”

Skin Cells Turned Directly Into the Cells That Insulate Neurons

Apr. 15, 2013 — Researchers at the Stanford University School of Medicine have succeeded in transforming skin cells directly into oligodendrocyte precursor cells, the cells that wrap nerve cells in the insulating myelin sheaths that help nerve signals propagate.
The current research was done in mice and rats. If the approach also works with human cells, it could eventually lead to cell therapies for diseases like inherited leukodystrophies — disorders of the brain’s white matter — and multiple sclerosis, as well as spinal cord injuries. The study will be published online April 14 in Nature Biotechnology.
Without myelin to insulate neurons, signals sent down nerve cell axons quickly lose power. Diseases that attack myelin, such as multiple sclerosis, result in nerve signals that are not as efficient and cannot travel as far as they should. Myelin disorders can affect nerve signal transmission in the brain and spinal cord, leading to cognitive, motor and sensory problems.
Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms. “Unfortunately, the availability of human fetal tissue is extremely limited, and the creation of OPCs from embryonic stem cells is slow and tedious,” said the study’s senior author, Marius Wernig, MD, assistant professor of pathology and a member of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine. “It appeared we wouldn’t be able to create enough human OPCs for widespread therapeutic use, so we began to wonder if we could create them directly from skin cells.”
Nan Yang, PhD, a postdoctoral scholar in the Wernig laboratory and lead author of the study, pointed out that there is another advantage to using this technique. “By using the patient’s own skin cells, we should be able to generate transplantable OPCs that are genetically identical to the patient’s natural OPCs,” Yang said. “This allows us to avoid the problem of immune rejection, which is a major complication in transplantation medicine.”
Last year, Wernig’s team successfully created human nerve cells out of skin cells. Other researchers had successfully used a similar process to turn skin cells into embryonic-like cells called induced pluripotent stem cells, and then grow those iPS cells into nerve cells, but Wernig’s lab was the first to convert skin cells directly into nerve cells without the intermediate iPS cell step.
The team’s current research project also involved directly converting skin cells into OPCs without having to create iPS cells. The researchers showed that mouse and rat skin cells could be directly converted into OPCs, and that these cells would successfully myelinate nerve cells when transplanted into the brains of mice with a myelin disorder.
Next, the team plans to reproduce the research in human cells; if successful, the approach could lay the groundwork for therapies for a wide array of myelin disorders and spinal cord injury.

Stanford School of Medicine Validates Cellular Transformation!

Stanford University School of Medicine validates Dr. Robert O. Young’s cellular transformation research.


Pleomorphism is a scientific doctrine originally suggested by French medical doctor and researcher Dr. Antione BeChamp in the late 1800’s. He suggested that plant, animal and human cells will biologically transform into different cells depending on environmental factors. Such as a red blood cell would morph or transform into white blood cell or a white blood cell could morph or transform into a body cell such as a connective tissue cell. Dr. BeChamp also suggested that a body cell would transform into a bacterial cell or a yeast cell when there was a declining alkaline pH of the environment. In other words, the germ is born in us and from us out of a transforming blood or body cell.

The foundation of my theory is that the red blood cell is the foundational stem cell that can become all other body cells, including white blood cells, brain cells, bones cells, liver cells or muscles cells, etc. All cell transformations are pH or environment sensitive. For example, when the pH begins to decline from 7.365 to 7.2, the red blood cell will morph into bacteria, then yeast and finally mold. In other words healthy blood and body cells will transform into bacteria and than mold in a declining pH just like the food in the refrigerator as it ages or spoils from a compromised alkaline environment.

The cell transformations of healthy cells to cancerous cells and then back to healthy cells is also triggered by the acidity or alkalinity or the environment in which these cells are found. I have explained this natural phenomenon in a simple metaphor – when the fish is sick what would you do treat the fish or change the water? The correct answer is change the water! Why? Because the fish is only as healthy as the water in which it resides and swims. This is also true for plant, animal and human blood and body cells.
I have suggested for over 3 decades that the human body is alkaline by design although acidic by function. When acidic metabolic waste products are NOT properly eliminated through the four channels of elimination than these toxins or acids build-up in the connective and fatty tissues setting the stage for cell transformations that lead to enervation, irritation, inflammation, induration, ulceration and finally degeneration.
The scientists at Stanford University have just recently validated my research and confirmed the pleomorphic research of Dr. Antione BeChamp. Dr. BeChamp was right and Pasteur was wrong. The germ is NOTHING and the TERRAIN is everything!

I also documented these biological cell transformations over 20 years ago in 1994 before the investigators from Stanford University. It feels good to know you are not alone and other scientists are finally viewing cell transformation which was first discovered by Dr. Antione BeChamp over 100 years ago and rediscovered by Dr. Robert O. Young over 20 years ago. It’s about time!

To learn more about the science of Dr. Robert O. Young and cell transformations read Sick and Tired, Reclaim Your Inner Terrain – www.phmiracle.com, www.phoreveryoung.com,www.phoreveryoung.wordpress.com

Watch the following video of a rod bacterial form transform into a red blood cell as recorded by Dr. Robert O. Young in 1994.

Watch the following video of a rod bacteria transform into a red blood cell as recorded by Dr. Robert O. Young in 1994.

To learn more about the science of Dr. Robert O. Young and cell transformations read Sick and Tired, Reclaim Your Inner Terrain – www.phmiracle.com, www.phoreveryoung.com,www.phoreveryoung.wordpress.com

Click here to read the article on cell transformation or pleomorphism: https://m.facebook.com/story.php…